Antihistamine drug withdrawn by manufacturer

Accidental Poisoning with the Antihistamine Drug "Histantin"

Professor Hewer. I will ask Dr. Apley, who looked after this child, to give us the finical history. i PrJohn Apley. Let me first tell you about the family of this little girl, an only ?hild, who died in hospital three days before her first birthday. The father is a man in ftls early thirties, who owns a shop. The mother is a kind and pleasant woman of some ^venty years of age. They live in a sm...

Cross Reference by Manufacturer

860−4490 72−120 . . . . . . . . . . . . . . . . . . 860−4500 72−144 . . . . . . . . . . . . . . . . . . 860−4505 72−145 . . . . . . . . . . . . . . . . . . 860−4510 72−163 . . . . . . . . . . . . . . . . . . 860−4515 72−164 . . . . . . . . . . . . . . . . . . 860−4520 72−133−0 . . . . . . . . . . . . . . . . 860−4522 72−134−2 . . . . . . . . . . . . . . . . 860−4523 72−134−0 . . . . . . . . . ....

Abstract withdrawn by author

H(1) antihistamine drug promethazine directly blocks hERG K(+) channel.

Promethazine is a phenothiazine derivative with antihistaminic (H(1)), sedative, antiemetic, anticholinergic, and antimotion sickness properties that can induce QT prolongation, which may lead to torsades de pointes. Since block of cardiac human ether-a-go-go-related gene (hERG) channels is one of the leading causes of acquired long QT syndrome, we investigated the acute effects of promethazine...

Abstract withdrawn by the author

withdrawn by the author